Cerebral malaria dissertation

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Which is the most severe neurological manifestation of malaria?

Cerebral malaria is the most severe neurological manifestation of severe malaria. With an incidence of 1,120/100,000/year in the endemic areas of Africa, children in this region bear the brunt. Peak incidence is in pre-school children and at a minimum, 575,000 children in Africa develop cerebral malaria annually(2).

How is cerebral malaria treated in the US?

Without treatment, cerebral malaria is invariably fatal. In children, parenteral antimalarials (cinchonoids or artemisinin derivatives) are indicated, but even with this treatment, 15-20% die. In adults however, mortality was lower if patients were treated with intravenous artesunate ( 11 ).

How does Plasmodium falciparum affect the brain?

Plasmodium falciparum is epileptogenic and the risk of seizures increases with parasitemia(55). Seizures are a common feature of childhood cerebral malaria; over 80% are admitted with seizures and seizures recur in 60% during admission(56).

How many people die each year from malaria?

One percent of symptomatic infections may become complicated and develop into severe malaria. Severe malaria may manifest as anemia, hypoglycemia, metabolic acidosis, repeated seizures, coma or multiple organ failure and is estimated to cause over one million deaths annually(1).

Last Update: Oct 2021

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